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Prenatal inflammation and neurodevelopment in schizophrenia: A review of human studies

Authors
Journal
Progress in Neuro-Psychopharmacology and Biological Psychiatry
0278-5846
Publisher
Elsevier
Publication Date
Volume
42
Identifiers
DOI: 10.1016/j.pnpbp.2012.03.010
Keywords
  • Cytokines
  • Infection
  • Inflammation
  • Neurodevelopment
  • Pregnancy
  • Schizophrenia

Abstract

Abstract A confluence of evidence supports an association between prenatal inflammation and risk of schizophrenia. Outside of studies of prenatal infections and risk of schizophrenia, other relevant human studies of prenatal inflammation and neurodevelopment in schizophrenia have not been reviewed. In this paper, we review human studies of 1) prenatal inflammation and risk of schizophrenia, 2) inflammation as a potential common mediator of several prenatal risk factors for schizophrenia other than prenatal infections, 3) prenatal inflammation and immune function, neurocognition, brain morphology, and gene expression in adult offspring with schizophrenia, and 4) gene by environment and gene by gene interactions relevant to these associations. We suggest future areas for human studies research based on existing findings.

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