Affordable Access

deepdyve-link
Publisher Website

14-3-3ζ mediates an alternative, non-thermogenic mechanism in male mice to reduce heat loss and improve cold tolerance

Authors
  • Diallo, Kadidia1, 2
  • Dussault, Sylvie2
  • Noll, Christophe3, 4
  • Lopez, Angel F.5
  • Rivard, Alain1, 2
  • Carpentier, André C.3, 4
  • Lim, Gareth E.1, 2
  • 1 Département de médecine, Université de Montréal, Montréal, QC, Canada
  • 2 Axe cardio-métabolique, Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM), Montréal, Québec, Canada
  • 3 Département de médecine, Université de Sherbrooke, Sherbrooke, QC, Canada
  • 4 Centre de Recherche du Centre Hospitalier de l’Université de Sherbooke (CHUS), Sherbrooke, QC, Canada
  • 5 Centre for Cancer Biology, SA Pathology and University of South Australia, Adelaide, South Australia, Australia
Type
Published Article
Journal
Molecular Metabolism
Publisher
Elsevier BV
Publication Date
Jul 12, 2020
Volume
41
Identifiers
DOI: 10.1016/j.molmet.2020.101052
PMID: 32668300
PMCID: PMC7394917
Source
PubMed Central
Keywords
License
Unknown

Abstract

• 14-3-3ζ over-expression in male mice improves tolerance to acute and prolonged cold. • Increasing 14-3-3ζ expression promotes beiging of inguinal white adipose tissue. • Cold-induced changes in body temperature can be dissociated from energy expenditure. • 14-3-3ζ-dependent decreases in heat loss are associated with vasoconstriction.

Report this publication

Statistics

Seen <100 times