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Lambert-Eaton myasthenic syndrome revealing an abdominal neuroblastoma

Authors
Journal
Journal of Pediatric Surgery
0022-3468
Publisher
Elsevier
Publication Date
Volume
44
Issue
8
Identifiers
DOI: 10.1016/j.jpedsurg.2009.04.023
Keywords
  • Neuroblastoma
  • Paraneoplastic
  • Myasthenic Syndrome
  • Lambert-Eaton
Disciplines
  • Medicine

Abstract

Abstract Lambert-Eaton myasthenic syndrome is a paraneoplastic syndrome that may reveal a primitive tumor. Neuroblastoma in children and small cell lung carcinoma in adults are the leading tumors revealed or expressed by paraneoplastic phenomena. The clinical neurologic manifestations of Lambert-Eaton myasthenic syndrome are muscular weakness, sleepiness, absence of reflexes, and dysautonomia. Neurologic manifestations are explained by the induction of an autoimmune response because of the presence of antigens that are expressed by the tumor. Neurologic paraneoplastic disorders may also be the result of toxicity of drugs, coagulopathy, infection, or metabolic diseases. We describe the case of a 13-month-old child with unusual neurologic symptoms because of the presence of an abdominal neuroblastoma.

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