Affordable Access

Publisher Website

A kinetic model for phosphofructokinase based on the paradoxical action of effectors

Authors
Journal
Biochemical and Biophysical Research Communications
0006-291X
Publisher
Elsevier
Publication Date
Volume
68
Issue
3
Identifiers
DOI: 10.1016/0006-291x(76)91236-5
Disciplines
  • Biology

Abstract

Abstract Effectors of muscle phosphofructokinase show opposing action on the activity of the enzyme depending upon the concentration of phosphoryl donor employed in the assay. Established inhibitors, such as citrate, activate at low ATP or ITP concentrations while known activators, such as AMP, ADP, and cyclic AMP inhibit at low ATP or ITP concentrations. Inorganic phosphate, on the other hand, activates at all substrate concentrations. The paradoxical effects at low substrate concentrations are dependent upon the order of addition of reaction components. A model is proposed to explain these and other regulatory phenomena of phosphofructokinase.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

A kinetic model for phosphofructokinase based on t...

on Biochemical and Biophysical Re... Feb 09, 1976

Kinetic modelling of yeast phosphofructokinase.

on Acta biologica et medica Germa... 1979

A model for glycolytic oscillations based on skele...

on Journal of Theoretical Biology May 21, 1995
More articles like this..