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Synthesis and 5-HT3receptor agonist activity of arylureas derived from histamine.

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
3
Issue
2
Identifiers
DOI: 10.1016/s0960-894x(01)80877-5

Abstract

Abstract The synthesis of a series of aryl ureas derived from histamine is described. The compounds are shown to be 5-HT 3 receptor agonists by their ability to initiate the Bezold-Jarisch reflex and to displace [ 3H]-BRL 3694 from central 5-HT 3 receptors with a potency equivalent to that of 5-HT.

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