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1,3-diphenylpropan-1-ones as allosteric modulators of α7 nACh receptors with analgesic and antioxidant properties.

Authors
  • Criado, Manuel1
  • Balsera, Beatriz2
  • Mulet, José1
  • Sala, Salvador1
  • Sala, Francisco1
  • de la Torre-Martínez, Roberto3
  • Fernández-Carvajal, Asia3
  • Ferrer-Montiel, Antonio3
  • Moreno-Fernández, Silvia4
  • Miguel, Marta4
  • Pérez de Vega, María Jesús2
  • González-Muñiz, Rosario2
  • 1 Instituto de Neurociencias, Universidad Miguel Hernández-CSIC, 03050 Sant Joan d'Alacant, Spain. , (Spain)
  • 2 Instituto de Química Médica, IQM-CSIC, Juan de la Cierva 3, 28006 Madrid, Spain. , (Spain)
  • 3 Instituto de Biología Molecular y Celular, Universidad Miguel Hernández, Avenida de la Universidad s/n, 03202 Elche (Alicante), Spain. , (Spain)
  • 4 Instituto de Investigación en Ciencias de la Alimentación (CSIC-UAM, CEI+UAM), C/Nicolás Cabrera 9, 28049 Madrid, Spain. , (Spain)
Type
Published Article
Journal
Future Medicinal Chemistry
Publisher
"Future Science, LTD"
Publication Date
May 01, 2016
Volume
8
Issue
7
Pages
731–749
Identifiers
DOI: 10.4155/fmc-2015-0001
PMID: 27161515
Source
Medline
Keywords
License
Unknown

Abstract

Compound 31 is a novel, potent and selective α7 nAChR PAM, displaying antioxidant and analgesic activities. The 1,3-diphenylpropan-1-one scaffold could be the base toward more advanced type I PAMs for the treatment of nAChR-mediated diseases.

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