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First biological images with high-energy proton microscopy

Authors
Journal
Physica Medica
1120-1797
Publisher
Elsevier
Volume
29
Issue
2
Identifiers
DOI: 10.1016/j.ejmp.2012.03.002
Keywords
  • Proton Radiography
  • Proton Therapy
  • Image-Guided Radiotherapy
  • Radiosurgery
  • Proton Microscopy
Disciplines
  • Biology
  • Medicine

Abstract

Abstract High-energy proton microscopy provides unique capabilities in penetrating radiography including the combination of high spatial resolution and field-of-view, dynamic range of density for measurements, and reconstructing density variations to less than 1% inside volumes and in situ environments. We have recently proposed to exploit this novel proton radiography technique for image-guided stereotactic particle radiosurgery. Results of a first test for imaging biological and tissue-equivalent targets with high-energy (800 MeV) proton microscopy are presented here. Although we used a proton microscope setup at ITEP (Moscow, Russia) optimized for fast dynamic experiments in material research, we could reach a spatial resolution of 150 μm with approximately 1010 protons per image. The potential of obtaining high-resolution online imaging of the target using a therapeutic proton beam in the GeV energy region suggests that high-energy proton microscopy may be used for image-guided proton radiosurgery.

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