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Nonserotonergic control of nucleus accumbens dopamine metabolism by the median raphe nucleus

Authors
Journal
Pharmacology Biochemistry and Behavior
0091-3057
Publisher
Elsevier
Publication Date
Volume
41
Issue
3
Identifiers
DOI: 10.1016/0091-3057(92)90364-l
Keywords
  • Median Raphe Nucleus
  • Gaba
  • Muscimol
  • Serotonin
  • Dopamine
  • Nucleus Accumbens
  • Hyperactivity

Abstract

Abstract Injections of the GABA agonist muscimol into the median raphe nucleus (MR) have been shown to result in an acceleration of dopamine metabolism within the nucleus accumbens. To examine whether serotonergic mechanisms play a role in this effect, muscimol or its vehicle was injected into the MR of either control subjects or of rats that had received prior injections of the serotonin-depleting agent p-chlorophenylalanine (PCPA). Although PCPA treatments produced massive depletions of forebrain serotonin, they failed to alter the effect of muscimol infusions on dopamine metabolism. This finding suggests that the effects of intra-MR injections of muscinol on accumbens dopamine turnover do not result entirely from an interaction between serotonergic and dopaminergic systems.

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