Affordable Access

Publisher Website

Identification of a secondMycobacterium tuberculosisgene cluster encoding proteins of an ABC phosphate transporter

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
394
Issue
2
Identifiers
DOI: 10.1016/0014-5793(96)00953-2
Keywords
  • Atp-Binding-Cassette Transporter
  • Phosphate Transport
  • Psts
  • Pstc
  • Ag 88
Disciplines
  • Biology

Abstract

Abstract Following the identification of a M. tuberculosis phosphate transporter belonging to the superfamily of ABC transporters, we report on the cloning and sequencing of two additional genes, called pstS-3 and pstC-2, encoding proteins homologous to PstS and PstC of Escherichia coli, respectively. Together with the previously isolated M. tuberculosis gene similar to the E. coli pstA, these are included in a cluster encoding a second putative phosphate transport system. We demonstrate that pstS-3 encodes the previously described Ag 88, a 40 kDa M. bovis BCG culture filtrate antigen (immunodominant in H-2 b haplotype type mice). Finally, a signature motif identifying integral transmembrane proteins of prokaryotic phosphate binding-dependent permeases is proposed.

There are no comments yet on this publication. Be the first to share your thoughts.