Affordable Access

Publisher Website

Acquired tamoxifen resistance in human breast cancer and reduced intra-tumoral drug concentration

Authors
Journal
The Lancet
0140-6736
Publisher
Elsevier
Publication Date
Volume
342
Identifiers
DOI: 10.1016/s0140-6736(05)80088-1
Disciplines
  • Biology
  • Medicine

Abstract

Reduced intra-tumoral drug concentrations have been investigated as a mechanism of tamoxifen resistance in 51 patients with locally recurrent breast cancer. Serum tamoxifen was similar in patients with acquired and de-novo resistance, but intra-tumoral concentrations were significantly lower in patients with acquired resistance. Tumour oestrogen-receptor concentrations at relapse did not support the hypothesis that selective outgrowth of oestrogen-receptor-negative cells is a major mechanism for acquired tamoxifen resistance. Reduced intra-tumoral tamoxifen levels during prolonged therapy may be an important mechanism for acquired resistance in breast cancer.

There are no comments yet on this publication. Be the first to share your thoughts.