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American Diabetes Association
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DOI: 10.2337/db11-er12
  • Errata
  • Medicine


Varney MD, Valdes AM, Carlson JA, Noble JA, Tait BD, Bonella P, Lavant E, Fear AL, Louey A, Moonsamy P, Mychaleckyj JC, Erlich H, for the Type 1 Diabetes Genetics Consortium. HLA DPA1, DPB1 alleles and haplotypes contribute to the risk associated with type 1 diabetes: analysis of the Type 1 Diabetes Genetics Consortium families. Diabetes 2010;59:2055–2062 In a recent re-examination of the data in the article listed above, we have detected an error in the determination by segregation of DPA1-DPB1 haplotypes. The determination of DPA1-DPB1 haplotypes by segregation has been re-calculated and confirmed manually using the latest dataset available from the Type 1 Diabetes Genetics Consortium (T1DGC); the results are shown below. The initially reported observations of a type 1 diabetes risk associated with DPB1*0301 (DPA1*0103-DPB1*0301) and DPB1*0202 (DPA1*0103-DPB1*0202) and protection with DPB1*0402 (DPA1*0103-DPB1*0402) remain valid; in the new analysis, the associations were significant when comparisons were made directly (unadjusted for linkage disequilibrium), conditional on HLA-(B)-DRB1-DQA1-DQB1 linkage disequilibrium and, except DPB1*0202, in the absence of the primary DR-DQ associations (relative predispositional analyses). However, the initially reported observation of the protective association with DPA1*0103-DPB1*0101 but not DPA1*0201-DPB1*0101 was invalid because, in our revised and corrected haplotype determination, the haplotype DPA1*0103-DPB1*0101 was not observed. We gratefully acknowledge the contribution of Wolfgang Helmberg in the revised DPA1-DPB1 haplotype segregation. TABLE 1 Proband and affected family-based control (AFBAC) HLA DPA1, DPB1 allele and DPA1-DPB1 haplotype frequency distribution in 1,718 Caucasian type 1 diabetic families AFBAC (%) (n = 2,565) Proband (%) (n = 3,435) P adj Odds ratio

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