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Ceramide/sphingosine/sphingosine 1-phosphate metabolism on the cell surface and in the extracellular space

Authors
Journal
Cellular Signalling
0898-6568
Publisher
Elsevier
Publication Date
Volume
19
Issue
2
Identifiers
DOI: 10.1016/j.cellsig.2006.07.001
Keywords
  • Ceramide
  • Sphingosine
  • Sphingosine 1-Phosphate
  • Acid Sphingomyelinase
  • Alkaline Sphingomyelinase
  • Neutral Ceramidase
  • Sphingosine Kinase
Disciplines
  • Biology

Abstract

Abstract Sphingolipid metabolites, ceramide, sphingosine, and sphingosine 1-phosphate, have emerged as a new class of lipid biomodulators of various cell functions. These metabolites are known to function not only as intracellular second messengers, but also in the extracellular space. Sphingosine 1-phosphate especially has numerous functions as an important extracellular mediator that binds to cell surface S1P receptors. Recent studies have also shown that sphingolipid-metabolizing enzymes function not only in intracellular organelles but also in the extracellular spaces, including the outer leaflet of the plasma membrane. This review focuses on the metabolic enzymes (acid and alkaline sphingomyelinases, neutral ceramidase, and sphingosine kinase) that are involved in the production of the sphingolipid metabolites in these extracellular spaces, and on the metabolic pathway itself.

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