Affordable Access

Publisher Website

Interleukin-1 as intermediary causing prolonged sleep apnea and SIDS during respiratory infections

Authors
Journal
Medical Hypotheses
0306-9877
Publisher
Elsevier
Publication Date
Volume
28
Issue
2
Identifiers
DOI: 10.1016/0306-9877(89)90025-x
Disciplines
  • Biology
  • Medicine

Abstract

Abstract Two epidemiologic features of sudden infant death sydrome, respiratory infections and prolonged sleep apnea, have not been linked by a known mechanism. Muramyl peptide, acting through interleukin-1, is proposed as that link. Both agents produce fever, activation of the immune system, and of particular significance, increased deep or slow wave sleep. Although sleep apnea is universal, prolonged apnea can, if uninterupted by arousal, lead to hypoxic apnea, coma, and death. Infants in the first six months of life are particularly vulnerable when arousal mechanisms may not be fully developed, after 9 months of fetal life when life does not depend on respiration.

There are no comments yet on this publication. Be the first to share your thoughts.