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Cupric sulfate pentahydrate (CuSO4·5H2O): a mild and efficient catalyst for tetrahydropyranylation/depyranylation of alcohols and phenols

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
45
Issue
42
Identifiers
DOI: 10.1016/j.tetlet.2004.08.141
Keywords
  • Protection Of Hydroxyl Compounds

Abstract

Abstract Various alcohols and phenols can be smoothly converted to the corresponding THP ethers using 20 mol % CuSO 4·5H 2O under mild reaction conditions at room temperature. Some of the major advantages of this procedure are nonaqueous work-up, very good yields, less expensive catalyst and compatibility with other protecting groups.

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