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Catecholamine release in human heart by bupropion

Authors
Publisher
Elsevier B.V.
Publication Date
Volume
467
Identifiers
DOI: 10.1016/s0014-2999(03)01600-5
Keywords
  • Bupropion
  • Heart
  • Contractility
  • Catecholamine
  • Amphetamine
Disciplines
  • Medicine
  • Pharmacology

Abstract

Abstract Although there are some data on the cardiovascular profile of bupropion, a non-nicotine-based pharmacotherapy for smoking cessation, detailed studies of its specifically cardiac effects are lacking. In particular, the direct action of this agent on human myocardial contractility is not known. Therefore, we investigated the effects of bupropion on human cardiac tissue in vitro. Our results suggest that bupropion exerts indirect sympathomimetic activity producing positive inotropic effects in human myocardium most probably by catecholamine release.

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