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Common Endocrine Diseases in Domestic Animals

Sestre Milosrdnice University hospital and Institute of Clinical Medical Research; [email protected]
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  • Biology
  • Chemistry
  • Ecology
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  • Medicine


Acta 2 Book.indb Acta Clin Croat, Vol. 49, No. 2, 2010 221 Acta Clin Croat 2010; 49:211-243 Conference Papers LECTURES COMMON ENDOCRINE DISEASES IN DOMESTIC ANIMALS Th . J. Rosol Ohio State University, Columbus, OH, USA Th omas J. Rosol, DVM, PhD is Professor of Vet- erinary Pathology at Th e Ohio State University and is board certifi ed by the American College of Veterinary Pathologists. His specialty is endocrine and reproduc- tive pathology. Prof. Rosol has authored over 210 papers and mentored over 35 trainees. He currently serves as an advisor for National Institutes of Health and the United States Department of Agriculture. Prof. Rosol will lecture on four common endocrine disorders in domestic and laboratory animals that have similarities to human conditions and emphasize the importance of comparative endocrinology: (1) Hyper- thyroidism in cats is a spontaneous, idiopathic disease of older cats. Its incidence has increased dramatically in the past 20 years. Aff ected cats suff er from clini- cal hyperthyroidism. Treatment consists of surgery or 131-Iodide. Th is condition mimics toxic nodular goiter of humans; (2) pars intermedia adenomas occur frequently in older horses and induce a clinical syn- drome due to secretion of multiple hormones derived from the precursor hormone, pro-opiomelanocortin; (3) Cushing’s disease occurs in dogs due to hyperglu- cocorticoidism induced by functional adrenal cortical tumors or adenomas of the pars distalis. Th e clinical syndrome is similar to that in humans. Th e aff ected dogs can be treated with drugs that are toxic to the adrenal cortex, such as mitotane; and (4) C-cell hy- perplasia and adenomas occur frequently in older rats and can be induced by environmental chemicals or medical drugs. A new class of antidiabetic drugs is being developed based on stimulation of glucagon- like peptide (GLP-1) receptors. GLP-1 receptor ago- nists induce C-cell hyperplasia and adenomas in rats and mice, but do not ind

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