Affordable Access

Publisher Website

Stereoselective synthesis of methyl 3α-ethyl-1,2,3,4,6,7,12,12bβ-octahydroindolo[2,3-a]quinolizine-1α-carboxylate: A key intermediate for the preparation of tacamine-type indole alkaloids

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
37
Issue
9
Identifiers
DOI: 10.1016/0040-4039(96)00052-4

Abstract

Abstract Methyl 3α-1,2,3,4,6,7,12,12bβ-cotahydroindolo[2,3- a]quinolizine-1α-carboxylate ( 6), a key intermediate for the synthesis of tacamine-type indole alkaloids, was prepared in six simple steps from methyl 5-(1′-hydroxyethyl)nicotinate ( 7). The last step was the catalytic hydrogenation of the two ethylidene isomers 14 and 15, both of which gave the target ester stereoselectively.

There are no comments yet on this publication. Be the first to share your thoughts.