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Loss of hepatic monooxygenase activities, glutathione, and ‘green pigment’ formation after the administration of vinyl-cyclooctane to mice

Authors
Journal
Toxicology Letters
0378-4274
Publisher
Elsevier
Publication Date
Volume
16
Identifiers
DOI: 10.1016/0378-4274(83)90179-0
Keywords
  • Cytochrome P-450 Inactivation
  • Glutathione Depletion
  • Green Pigment Formation
  • Vinyl Cyclooctane Metabolism

Abstract

Abstract Vinylcyclooctane, when administered to mice at 500 mg/kg, produced reduction of microsomal cytochrome P-450, heme, aminopyrine- N-demethylase and ethoxycoumarin- O-deethylase activities with respect to control values; furthermore the hepatic reduced glutathione level was depleted suggesting that glutathione is involved in the vinylcyclooctane metabolism. The reduction of cytochrome P-450 and monooxygenase activities was accompanied by the formation of abnormal ‘green pigments’.

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