The first issue of Revista Médica de Chile was printed in July, 1872. Since then, it has been published monthly, interrupted only for a few months during a Chilean civil war (1891). This medical journal has been devoted mainly to clinical topics in internal medicine, but currently it includes an increasing proportion of research papers in other biomedical and preclinical subjects. This journal is included in the most important international indexes of biomedical publications. Most issues cover also medical education, public health, the ethics of clinical and experimental research, medical administration and the history of medicine. The evolution of medicine in Chile along 125 years is clearly reflected in the contents of this journal. Revista Médica de Chile is one of the oldest medical journals in the world, particularly among those published in Spanish, and a top ranking biomedical publication in Chile.