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Updates on Antiobesity Effect of Garcinia Origin (−)-HCA

Authors
Journal
Evidence-based Complementary and Alternative Medicine
1741-427X
Publisher
Hindawi Limited
Publication Date
Volume
2013
Identifiers
DOI: 10.1155/2013/751658
Source
Legacy
Keywords
  • Review Article
Disciplines
  • Chemistry

Abstract

Garcinia is a plant under the family of Clusiaceae that is commonly used as a flavouring agent. Various phytochemicals including flavonoids and organic acid have been identified in this plant. Among all types of organic acids, hydroxycitric acid or more specifically (−)-hydroxycitric acid has been identified as a potential supplement for weight management and as antiobesity agent. Various in vivo studies have contributed to the understanding of the anti-obesity effects of Garcinia/hydroxycitric acid via regulation of serotonin level and glucose uptake. Besides, it also helps to enhance fat oxidation while reducing de novo lipogenesis. However, results from clinical studies showed both negative and positive antiobesity effects of Garcinia/hydroxycitric acid. This review was prepared to summarise the update of chemical constituents, significance of in vivo/clinical anti-obesity effects, and the importance of the current market potential of Garcinia/hydroxycitric acid.

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