Abstract 1. 1. The s.c. administration of cortisol to hamsters (50 mg/kg body wt/day for 4 days) produces a significant increase in maltase sucrase, alkaline phosphatase and leucineaminopeptidase activity in intestinal mucosa. 2. 2. Lactase activity is unaffected by cortisol. 3. 3. Gamma-glutamyltranspeptidase activity increases slightly in females but remains unchanged in males. 4. 4. Cortisol causes increase in proline and glycine absorption without changing the absorption of lysine.