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6-Thioguanine as a cause of toxic veno-occlusive disease of the liver

Authors
Publication Date
Source
PMC
Keywords
  • Review Article
Disciplines
  • Medicine

Abstract

Lesions of hepatic veno-occlusive disease were found in the needle biopsy specimen of one patient suffering from chronic granulocytic leukaemia and in the liver at necropsy of a second patient suffering from acute myeloid leukaemia. The treatment included administration of 6-thioguanine which was the only relevant compound used in the first patient and which was combined with cytosine arabinoside in the second patient.

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