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Efficacies of Clarithromycin Regimens against Mycobacterium xenopi in Mice

Authors
Publisher
American Society for Microbiology
Publication Date
Source
PMC
Keywords
  • Experimental Therapeutics

Abstract

Mice were infected intravenously with 3.5 × 107 CFU of Mycobacterium xenopi and treated with various clarithromycin-containing regimens or left untreated for 4 weeks. All nine of the clarithromycin-containing regimens reduced the CFU counts to the levels below the pretreatment values, indicating that these regimens had a bactericidal effect on M. xenopi in mice. The rifampin-isoniazid-ethambutol regimen was significantly less bactericidal than clarithromycin alone or clarithromycin-containing combined regimens.

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