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12-month study of haloperidol decanoate in chronic schizophrenic patients.

Authors
  • Gelders, Y G
  • Reyntijens, A J
  • Ash, C W
  • Aerts, T J
Type
Published Article
Journal
International pharmacopsychiatry
Publication Date
Jan 01, 1982
Volume
17
Issue
4
Pages
247–254
Identifiers
PMID: 7185769
Source
Medline
License
Unknown

Abstract

239 psychotic patients entered a 52-week open study comparing the efficacy and safety of intramuscular haloperidol decanoate, injected once every 4 weeks, with that of their previous maintenance therapy. Haloperidol decanoate, given at a medium monthly dose of 100 mg provided a suitable substitute for oral neuroleptic mono- and polytherapy and intramuscular fluphenazine decanoate. Stabilization or slight improvement was observed for all ten symptoms selected from the BPRS. The drug provoked a low incidence of side-effects allowing reduction of antiparkinsonian medication and there were no significant haematological or biochemical changes.

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