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11p15.5 epimutations in children with Wilms tumor and hepatoblastoma detected in peripheral blood

Authors
  • Fiala, Elise M.1, 1
  • Ortiz, Michael V.1, 2
  • Kennedy, Jennifer A.1, 1
  • Glodzik, Dominik1
  • Fleischut, Megan Harlan1, 1
  • Duffy, Kelly A.3, 4, 3, 3
  • Hathaway, Evan R.3, 4, 3, 3
  • Heaton, Todd1, 2, 1
  • Gerstle, Justin T.1, 2, 1
  • Steinherz, Peter1, 2
  • Shukla, Neerav1, 2
  • McNeer, Nicole1
  • Tkachuk, Kaitlyn1
  • Bouvier, Nancy1
  • Cadoo, Karen1, 2, 1
  • Carlo, Maria I.1, 2, 1
  • Latham, Alicia1, 2, 1, 1
  • Dubard Gault, Marianne1
  • Joseph, Vijai1
  • Kemel, Yelena1
  • And 10 more
  • 1 Memorial Sloan Kettering Cancer Center
  • 2 Weill Cornell Medical College
  • 3 University of Pennsylvania
  • 4 Children's Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania
Type
Published Article
Journal
Cancer
Publisher
Wiley (John Wiley & Sons)
Publication Date
Apr 22, 2020
Volume
126
Issue
13
Pages
3114–3121
Identifiers
DOI: 10.1002/cncr.32907
PMID: 32320050
PMCID: PMC7383476
Source
PubMed Central
Keywords
License
Unknown
External links

Abstract

In the current study, all patients presenting with Wilms tumor or hepatoblastoma undergo 11p15.5 methylation analysis. Approximately one‐third are found to have an epimutation at this locus that is detectable in peripheral blood.

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