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Three years experience with denaturated venous homografts as an arterial substitute: A clinical, pathological and immunological study

Authors
Journal
European Journal of Vascular Surgery
0950-821X
Publisher
Elsevier
Publication Date
Volume
2
Issue
4
Identifiers
DOI: 10.1016/s0950-821x(88)80032-x
Keywords
  • Homologous Vein
  • Immunopathology
  • Femoro-Popliteal Reconstruction
  • Arterial Graft

Abstract

Over a three-year-period 105 peripheral arterial reconstructions were performed using a denaturated venous homograft in a group of patients with no suitable autologous vein. A retrospective analysis has been carried out to investigate the potency rate of this graft. After three years 64% of all grafts are functioning well (according to the Life Table Method, Kaplan & Meyer). No significant differences in patency rates were found between reversed autologous veins and the material tested in this study but analysis of grafts removed after failure showed obstruction due to thrombosis or aneurysmal dilatation. No evidence of an immune response to the grafts was seen.

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