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The effect of preoperative aspirin-free interval on red blood cell transfusion requirements in cardiac surgical patients

Authors
Journal
Journal of Cardiothoracic and Vascular Anesthesia
1053-0770
Publisher
Elsevier
Volume
16
Issue
1
Identifiers
DOI: 10.1053/jcan.2002.29674
Keywords
  • Aspirin
  • Cardiac Surgery
  • Blood Loss
  • Blood Transfusion
Disciplines
  • Education
  • Medicine

Abstract

Abstract Objective: To compare red blood cell transfusion in first-time coronary artery surgery patients who stopped taking aspirin ≤2 days, 3 to 7 days, or >7 days preoperatively. Design: Observational study. Setting: University-affiliated teaching hospital. Participants: Adult patients (n = 797) undergoing first-time coronary artery surgery on cardiopulmonary bypass who were not receiving other anticoagulant or antiplatelet drugs before surgery. Interventions: None. Measurements and Main Results: Patients were divided into 4 groups based on days since last ingestion of aspirin. Blood products transfused in the groups were (aspirin ≤2 days) (n = 140) 2.2 ± 4 U of red cell concentrate (RCC) (mean ± SD), 1.4 ± 3 U of fresh frozen plasma (FFP), and 2.7 ± 6 U of platelets; (aspirin 3 to 5 days) (n = 255), 1.5 ±2 U of RCC, 0.8 ± 2 U of FFP, and 1.6 ± 4 U of platelets; (aspirin 6 to 7 days) (n = 215), 1.6 ± 3 U of RCC, 0.9 ± 3 U of FFP, and 1.5 ± 3 U of platelets; and (aspirin >7 days) (n = 187), 1.3 ± 2 U of RCC; 0.6 ± 2 U of FFP, and 0.9 ± 2 U of platelets. Conclusion: Patients who stop taking aspirin ≤2 days preoperatively have increased allogenic red blood cell transfusion requirements perioperatively. Patients who stop taking aspirin 3 to 7 days preoperatively have little or no increased requirement for allogenic red blood cell transfusion. Copyright 2002, Elsevier Science (USA). All rights reserved.

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