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High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome

Authors
Publisher
BioMed Central
Publication Date
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PMC
Keywords
  • Research Article
Disciplines
  • Biology
  • Ecology
  • Medicine

Abstract

bcr977.fm Available online http://breast-cancer-research.com/content/7/2/R194 Open AccessVol 7 No 2Research article High expression of focal adhesion kinase (p125FAK) in node-negative breast cancer is related to overexpression of HER-2/neu and activated Akt kinase but does not predict outcome Klaus Jürgen Schmitz1, Florian Grabellus1, Rainer Callies2, Friedrich Otterbach1,3, Jeremias Wohlschlaeger1, Bodo Levkau4, Rainer Kimmig2,3, Kurt Werner Schmid1,3 and Hideo Andreas Baba1 1Institute of Pathology, University Hospital of Essen-Duisburg, Essen, Germany 2Department of Obstetrics and Gynecology, University Hospital of Essen-Duisburg, Essen, Germany 3West German Cancer Centre, Essen, Germany 4Institute of Pathophysiology, University Hospital of Essen-Duisburg, Essen, Germany Corresponding author: Hideo Andreas Baba, [email protected] Received: 17 Aug 2004 Revisions requested: 9 Nov 2004 Revisions received: 22 Nov 2004 Accepted: 26 Nov 2004 Published: 7 Jan 2005 Breast Cancer Res 2005, 7:R194-R203 (DOI 10.1186/bcr977)http://breast-cancer-research.com/content/7/2/R194 © 2005 Schmitz et al., licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/ 2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is cited. Abstract Introduction Focal adhesion kinase (FAK) regulates multiple cellular processes including growth, differentiation, adhesion, motility and apoptosis. In breast carcinoma, FAK overexpression has been linked to cancer progression but the prognostic relevance remains unknown. In particular, with regard to lymph node-negative breast cancer it is important to identify high-risk patients who would benefit from further adjuvant therapy. Methods We analyzed 162 node-negative breast cancer cases to determine the prognostic relevance of FAK expression, and we investigated the relationship o

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