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Influence of the cation in condensation of glyoxylic acid on phenols in aqueous hydroxide solution

DOI: 10.1016/s0926-9614(96)80025-6
  • Chemistry
  • Pharmacology


Publisher Summary Hydroxy and alkoxy aromatic aldehydes are very important products, used primarily as flavors and fragrances, secondly as intermediates in the manufacture of agrochemicals, pharmaceuticals, cosmetics and in the electroplating industry, etc. This chapter illustrates that the use of tetra-alkylammonium hydroxide in place of sodium hydroxide increases dramatically the paraselectivity of the condensation between guaiacol and glyoxylic acid in aqueous media. The other advantages are the possibility to increase the productivity, increasing initial concentration, with a lower ratio of base. The new conditions for condensation can be used for other 2 alloxyphenols for example 2 ethoxyphenol.

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