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A semisynthesis of isepamicin by fragmentation method

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
46
Issue
4
Identifiers
DOI: 10.1016/j.tetlet.2004.11.130
Keywords
  • Garamine
  • Isepamicin
  • Aminoglycoside
  • Antibiotics

Abstract

Abstract Garamine derivative, key intermediate, was obtained from acid cleavage of sisomicin derivative. Its subsequent product was glycosylated with 6-azido-2,3,4-tri- O-benzyl-6-deoxy-α- d-glucopyranosyl chloride using silver triflate as a promoter to give isepamicin.

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