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Rat liver BiP/GRP78 is down-regulated by a peroxisome-proliferator, clofibrate

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
308
Issue
2
Identifiers
DOI: 10.1016/0014-5793(92)81275-q
Disciplines
  • Biology

Abstract

Abstract Administration of clofibrate in rat results in down-regulation of several liver proteins and a vast induction of peroxisomal proteins. One protein was identified as BiP/GRP78 using antibodies and cDNA cloning. The level of mRNA was reduced by the drug.

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