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111In-labeled immunoconjugates (ICs) bispecific for the epidermal growth factor receptor (EGFR) and cyclin-dependent kinase inhibitor, p27Kip1.

Journal
Cancer Biotherapy & Radiopharmaceuticals
Publisher
Mary Ann Liebert
Publication Date
Apr 01, 2009
Volume
24
Issue
2
Identifiers
DOI: 10.1089/cbr.2008.0553
Keywords
Disciplines
  • Biology
License
Unknown

Abstract

Probing intranuclear proteins in breast cancer (BC) cells by using radiolabeled antibodies is restricted by delivery barriers presented by cell and nuclear membranes. Our aim was to construct immunoconjugates (ICs) bispecific for epidermal growth factor receptors (EGFRs) and the intranuclear cyclin-dependent kinase inhibitor (CDKI) p27(Kip1) modified with nuclear-localizing sequences (NLSs) to facilitate their nuclear uptake following EGFR-mediated internalization.

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