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111In-labeled immunoconjugates (ICs) bispecific for the epidermal growth factor receptor (EGFR) and cyclin-dependent kinase inhibitor, p27Kip1.

Authors
  • Cornelissen, Bart1
  • Kersemans, Veerle
  • McLarty, Kristin
  • Tran, Lara
  • Reilly, Raymond M
  • 1 Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, Canada. , (Canada)
Type
Published Article
Journal
Cancer Biotherapy & Radiopharmaceuticals
Publisher
Mary Ann Liebert
Publication Date
April 2009
Volume
24
Issue
2
Pages
163–173
Identifiers
DOI: 10.1089/cbr.2008.0553
PMID: 19409037
Source
Medline
License
Unknown

Abstract

We conclude that (111)In-labeled bispecific ICs were constructed that specifically bound EGFR and p27(Kip1). These ICs were internalized into BC cells expressing EGFR and HER2 and imported into the nucleus. Their decreased retention by cells with trastuzumab-modulated p27(Kip1) suggests that they may be useful for probing this CDKI by imaging.

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