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Evaluation of dextromethorphan and carbetapentane as anticonvulsants andN- methyl- d-aspartic acidantagonists in mice

Authors
Journal
Epilepsy Research
0920-1211
Publisher
Elsevier
Publication Date
Volume
4
Issue
1
Identifiers
DOI: 10.1016/0920-1211(89)90055-7
Keywords
  • Anticonvulsant
  • N- Methyl- D-Aspartic Acid
  • Phencyclidine
  • Dextromethorphan
  • Carbetapentane
Disciplines
  • Medicine

Abstract

Abstract Two antitussives, dextromethorphan and carbetapentane, which have been reported to bind to a common binding site in brain tissue and produce anticonvulsant effects in rats, were evaluated for their anticonvulsant effects against maximal electroshock-induced seizures, for their neurological impairing effects on the horizontal screen test, and their protective effects against N- methyl- d-aspartic acid (NMDA)-induced lethality in mice. Both compounds protected animals against maximal electroshock-induced seizures in a dose-related fashion after either intraperitoneal or oral administration. The neurologically impairing doses were approximately 1.5 times the anticonvulsant doses. As a function of dose, dextromethorphan, but not carbetapentane, protected mice from NMDA-induced lethality. Since carbetapentane had an anticonvulsant action without protecting against NMDA-induced lethality, these data support the hypothesis that dextromethorphan and carbetapentane may have a common anticonvulsant action separate from the phencyclidine-like, NMDA-antagonist action which only dextromethorphan exhibits.

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