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Posttetanic potentiation in strong and weak neuromuscular junctions: physiological differences caused by a differential Ca2+-influx

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
323
Issue
2
Identifiers
DOI: 10.1016/0006-8993(84)90304-4
Keywords
  • Neuromuscular Transmission
  • Posttetanic Potentiation
  • Miniature Endplate Potentials
  • Ca2+-Metabolism
  • Synaptic Plasticity
Disciplines
  • Biology

Abstract

Abstract We have sought physiological explanations for large differences in synaptic strength of different frog sartorius neuromuscular junctions, using the time course of posttetanic potentiation (PTP) of mEPP frequency as an indicator of the kinetics of Ca 2+-metabolism in junctions of varying strengths. Results obtained in Ca 2+ vs Ca 2+-free/EGTA Ringers suggest that differences in the Ca 2+-influx contribute to the physiological differences between strong and weak junctions.

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