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Microencapsulation of Traditional Chinese Herbs—PentaHerbs extracts and potential application in healthcare textiles

Authors
Journal
Colloids and Surfaces B Biointerfaces
0927-7765
Publisher
Elsevier
Publication Date
Volume
111
Identifiers
DOI: 10.1016/j.colsurfb.2013.05.036
Keywords
  • Healthcare Textiles
  • Pentaherbs
  • Atopic Dermatitis
  • Microencapsulation
Disciplines
  • Chemistry
  • Physics

Abstract

Abstract In this work, Traditional Chinese Herbs (TCH)—PentaHerbs—was successfully microencapsulated in chitosan–sodium alginate (CSA) blend matrix using emulsion-chemical cross-linking method and the final product was characterised with regard to structure, surface morphology, particle size, in vitro drug release and skin toxicity by means of Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), laser diffraction particle size analysis, high performance liquid chromatography (HPLC) and methyl thiazolyl tetrazolium (MTT) and lactate dehydrogenase (LDH) release assays respectively. Results showed that the microcapsules were in spherical form with diameter mostly in the range of 3–18μm and that the release performance of the microcapsules was influenced by pH value of phosphate buffer solution (PBS). The microcapsules had no toxic effects on cells and were successfully grafted onto the surface of cotton fabrics. These results indicated that PentaHerbs loaded CSA microcapsule may possess potential application in clinical treatment of atopic dermatitis (AD).

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