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Synthesis of a heptasaccharide fragment of the mannan fromCandida guilliermondiicell wall and its conjugate with BSA

Authors
Journal
Carbohydrate Research
0008-6215
Publisher
Elsevier
Publication Date
Volume
344
Issue
1
Identifiers
DOI: 10.1016/j.carres.2008.09.016
Keywords
  • Candida Guilliermondii
  • Mannan
  • Oligomannosides
  • Neoglycoconjugates
  • Synthesis

Abstract

Abstract The 3-aminopropyl glycoside of a heptasaccharide fragment of the cell wall mannan from Candida guilliermondii 18, which corresponds to the antigenic Factor 9, has been synthesized by a convergent approach based on glycosylation of a tetrasaccharide acceptor with a trisaccharide donor as the key step to give a protected heptasaccharide 17. Subsequent two-step deprotection of 17 afforded the heptamannoside 18, which was then conjugated with BSA using the squarate procedure.

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