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Alteration of biliary ursodeoxycholic acid in guinea pig during early stages of cholestyramine feeding

Authors
Journal
Steroids
0039-128X
Publisher
Elsevier
Publication Date
Volume
34
Issue
6
Identifiers
DOI: 10.1016/0039-128x(79)90140-5

Abstract

Abstract The effects of cholestyramine feeding on biliary ursodeoxycholic acid, fecal excretion of bile acids and neutral sterols on cholesterol 7α-hydroxylase and hepatic HMG-CoA reductase were examined in the guinea pig. In the bile there was a 57% decrease in the concentration of ursodeoxycholic acid while an increase was observed in the concentration of chenodeoxycholic acid. Cholestyramine feeding for ten days resulted in a decrease in plasma cholesterol levels and an increase in both hepatic HMG-CoA reductase and cholesterol 7α-hydroxylase activities. The fecal excretion of both bile acids and neutral sterols was significantly increased.

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