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Novel synthesis of CP-734432, an EP4 agonist, using Sharpless asymmetric dihydroxylation

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
51
Issue
11
Identifiers
DOI: 10.1016/j.tetlet.2009.12.092

Abstract

Graphical abstract A novel and efficient asymmetric route to CP-734432, a lactam analog of PGE2, that shows selective agonism against the EP4 receptor subtype, is reported herein. The key steps include a Heck coupling to introduce the aryl ring at C-16 and a highly diastereoselective Sharpless asymmetric dihydroxylation to set the C-15 center.

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