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Progesterone metabolismin vitroby ovaries from androgen-sterilized rats of different ages

Authors
Journal
Journal of Steroid Biochemistry
0022-4731
Publisher
Elsevier
Publication Date
Volume
9
Issue
7
Identifiers
DOI: 10.1016/0022-4731(78)90184-x

Abstract

Abstract Metabolism of [ 3H]-progesterone by ovarian homogenates from androgen-sterilized rats of different ages was examined. Ovaries of 26-day-old rats synthesized a significant quantity of 5α-reduced C 21-17-OH- and C 19-steroids. In contrast, ovaries of 40- and 55-day-old rats formed very little or no 5α-reduced C 21-17-OH- and C 19-steroids while significant amounts of 17α-hydroxy-4-pregnene-3,20-dione, 4-androstene-3,17-dione and testosterone were shown to be produced.

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