Affordable Access

Publisher Website

Comparative transcriptome analyses of Pseudomonas aeruginosa

Authors
Journal
Human Genomics
1473-9542
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
3
Issue
4
Identifiers
DOI: 10.1186/1479-7364-3-4-361
Keywords
  • Review
Disciplines
  • Biology
  • Ecology
  • Geography
  • Medicine

Abstract

One of the hallmarks of bacterial survival is their ability to adapt rapidly to changing environmental conditions. Niche adaptation is a response to the signals received that are relayed, often to regulators that modulate gene expression. In the post-genomic era, DNA microarrays are used to study the dynamics of gene expression on a global scale. Numerous studies have used Pseudomonas aeruginosa--a Gram-negative environmental and opportunistic human pathogenic bacterium--as the model organism in whole-genome transcriptome analysis. This paper reviews the transcriptome studies that have led to immense advances in our understanding of the biology of this intractable human pathogen. Comparative analysis of 23 P. aeruginosa transcriptome studies has led to the identification of a unique set of genes that are signal specific and a core set that is differentially regulated. The 303 genes in the core set are involved in bacterial homeostasis, making them attractive therapeutic targets.

There are no comments yet on this publication. Be the first to share your thoughts.