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Prediction of carbazole solubility and its dependence upon the solvent nature

Authors
Journal
International Journal of Pharmaceutics
0378-5173
Publisher
Elsevier
Publication Date
Volume
104
Issue
2
Identifiers
DOI: 10.1016/0378-5173(94)90187-2
Keywords
  • Carbazole
  • Solubility Prediction
  • Mobile Order Theory
  • Hydrogen Bond
  • Stability Constant
  • Solvent Effect
Disciplines
  • Physics

Abstract

Abstract On the basis of at most three parameters, the solubility of carbazole is predicted in 33 nonelectrolyte solvents by means of the general solubility equation derived from the thermodynamics of mobile order. Particular attention is focussed on the influence of the formation of solute-solvent stoechiometrical hydrogen bonds on the treatment of the non-specific dipole-dipole and dispersion interactions. Three classes of solvents can be distinguished according to their solubilizing potential towards carbazole: non-complexing solvents, complexing non-associated solvents and complexing amphiphilic solvents. The analysis of the relative importance of the different terms contributing to the solubility allows one to quantitatively understand its variation between the different classes as well as within each class of solvents.

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