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(1-34) Parathyroid hormone infusion acutely lowers fibroblast growth factor 23 concentrations in adult volunteers.

Authors
  • Gutiérrez, Orlando M
  • Smith, Kelsey T
  • Barchi-Chung, Allison
  • Patel, Neha M
  • Isakova, Tamara
  • Wolf, Myles
Type
Published Article
Journal
Clinical Journal of the American Society of Nephrology
Publisher
American Society of Nephrology
Publication Date
Jan 01, 2012
Volume
7
Issue
1
Pages
139–145
Identifiers
DOI: 10.2215/CJN.06240611
PMID: 22246283
Source
Medline
License
Unknown

Abstract

During short-term (1-34) PTH infusion, FGF23 levels decreased in parallel with serum phosphate levels and despite significant increases in 1,25(OH)(2)D. When coupled with the results of prior longer-term infusion studies, these findings suggest that acute increases in PTH initially act to suppress FGF23 secretion, perhaps to mitigate urinary phosphate losses, before the stimulatory effect of 1,25(OH)(2)D on FGF23 eventually begins to predominate.

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