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Foreword to special issue on homocysteine disorders

Journal of Inherited Metabolic Disease
Publication Date
DOI: 10.1007/s10545-010-9257-5
  • Editorial
  • Biology
  • Communication
  • Medicine


EDITORIAL Foreword to special issue on homocysteine disorders Brian Fowler & Henk J. Blom & Viktor Kožich Published online: 11 January 2011 # The Author(s) 2011. This article is published with open access at This special issue brings together a series of articles resulting from two recent symposia which focussed on homocysteine metabolism and related disorders. The 7th International conference on homocysteine metab- olism took place in Prague from the 21st to the 25th of June, 2009. This conference was the latest in the series following those held in Dromoland Castle Co. Clare, Ireland in 1995, in Nijmegen, the Netherlands in 1998, in Sorrento, Italy in 2001, in Basel, Switzerland in 2003, in Milan, Italy in 2005 and in Saarbrücken, Germany in 2007. In 2011 this meeting is planned to take place in Lisbon, Portugal. This conference tries to link basic science with clinical applications in the field of homocysteine, a field which has seen a dramatic increase in interest over the last 20 years. Current issues were addressed in Plenary sessions on: metabolites and their trafficking; genes; patho-physiology of disturbed C-1 and sulphur amino acid pool; 3 free communication sessions; 2 sessions on lessons from intervention trials and fortification. Two articles bring to attention two relatively poorly addressed pathways which could well be of increasing future importance. The extensive review by Ueland (doi:10.1007/ s10545-010-9088-4) on choline and betaine emphasises the importance of these metabolites in essential processes and recent studies on their possible links to chronic disease. The review by Stipanuk on the metabolic processes between cysteine and taurine and inorganic sulphur highlights that homocysteine can be a “good guy” in acting as precursor of this important pathway (doi:10.1007/s10545-010-9006-9). The key enzyme in homocysteine catabolism, cystathionine β-synthase, is central to three articles. The paper by Magner et al. (doi:10.1007/s10545-010-9146-y

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