Affordable Access

Publisher Website

Thiourea prevents cytotoxicity and mutagenicity, but not sister-chromated exchanges in V79 cells treated withcis-diaminedichloroplatinum(II)

Authors
Journal
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis
0027-5107
Publisher
Elsevier
Publication Date
Volume
96
Issue
1
Identifiers
DOI: 10.1016/0027-5107(82)90017-3

Abstract

Abstract This work shows that cis-diaminedichloroplatinum(II)'s ( cis-DDP) mutagenicity, as well as its cytotoxicity, can be prevented by subsequent treatment with thiourea. Sister-chromatid exchanges (SCE) induced by cis-DDP are only partially prevented by thiourea under conditions where mutagenicityy is totally inhibited. A 4.5-h delay in the addition of thiourea following cis-DDP treatment results in an almost complete loss of its ability to prevent mutagenicity, but only a partial loss of its ability to prevent cytotoxicity and sister-chromatid exchanges.

There are no comments yet on this publication. Be the first to share your thoughts.