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Effects of bifemelane on parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the common marmoset

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
178
Issue
1
Identifiers
DOI: 10.1016/0304-3940(94)90298-4
Keywords
  • Bifemelane
  • Common Marmoset
  • Mptp
  • Parkinsonism
  • Dopamine
  • Microdialysis
Disciplines
  • Medicine

Abstract

Abstract The effects of bifemelane on parkinsonism were shown in MPTP-treated common marmosets. The administration of bifemelane increased locomotor activity in MPTP-treated marmosets but not in normal control marmosets. In a microdialysis study, extracellular levels of dopamine and its metabolites increased following the administration of bifemelane. These results indicate that it is worth studying the effects of bifemelane hydrochloride on patients with Parkinson's disease.

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