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H-2 antigen restriction of viral infection (reply)

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  • Medizin
  • Ddc:610
  • Biology


H-2 antigen restriction of viral infection (reply) © Nature Publishing Group1975 sso baboons that I could see at the time were not unduly alarmed at my presence once they had reached the top of the cliff. MARTIN PICKFORD Department 0/ Geology, Queen Mary College, University 0/ London, Mile End Road, London EI 4NS, UK 1 Hamilton, W.J.,Buskirk,R.E., andBuskirk, W. H., Nature, 256, 488 (1975). H-2 antigen rt'striction of viral infection KOSZINOWSKI and Erd demonstrated1 that T lymphocytes immunised in vivo against virus kill virus-infected target cells only when these share H-2 antigens with the effector cells 2• The commonly expressed view 3 is that the effector T cells recognise an antigen created by an interaction of H-2K or H-2D antigen molecules with viral protein. To obtain further support for this notion, Koszinowski and Erd show convincingly that anti-H-2 serum blocks killing when it is directed against the target cells, but not when directed against the effector cells. An unfortunate nomen- clature (for example, anti-H-2kk for (H_2d/k x H_2bb) anti-H-2kk) gives the impression that the sera are directed against the antigens of the whole H-2 complex, when in fact both antisera used are directed only against the K end of the H-2 complex. Thus the H-2D antigens of the effector cells are still free, and one cannot rule out the alternative hypo- thesis!, that in order to kill, effector cells have to match up their SD antigens with those of the targets'. On the other hand, cytotoxicity is blocked completely whenever the anti- serum, be it an anti-H-2K or an anti- vaccinia serum, is directed against the target ceHs, and this is taken as evidence for an interaction product being the target. It is important to know whether a similar blocking could be caused by any antiserum directed against the target cells, or only by anti-H-2 or anti-virus serum. Two points are of particular interest in this respect. First, blocking of cytot

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