Affordable Access

H-2 antigen restriction of viral infection (reply)

Publication Date
  • Medizin
  • Ddc:610
  • Biology


H-2 antigen restriction of viral infection (reply) © Nature Publishing Group1975 sso baboons that I could see at the time were not unduly alarmed at my presence once they had reached the top of the cliff. MARTIN PICKFORD Department 0/ Geology, Queen Mary College, University 0/ London, Mile End Road, London EI 4NS, UK 1 Hamilton, W.J.,Buskirk,R.E., andBuskirk, W. H., Nature, 256, 488 (1975). H-2 antigen rt'striction of viral infection KOSZINOWSKI and Erd demonstrated1 that T lymphocytes immunised in vivo against virus kill virus-infected target cells only when these share H-2 antigens with the effector cells 2• The commonly expressed view 3 is that the effector T cells recognise an antigen created by an interaction of H-2K or H-2D antigen molecules with viral protein. To obtain further support for this notion, Koszinowski and Erd show convincingly that anti-H-2 serum blocks killing when it is directed against the target cells, but not when directed against the effector cells. An unfortunate nomen- clature (for example, anti-H-2kk for (H_2d/k x H_2bb) anti-H-2kk) gives the impression that the sera are directed against the antigens of the whole H-2 complex, when in fact both antisera used are directed only against the K end of the H-2 complex. Thus the H-2D antigens of the effector cells are still free, and one cannot rule out the alternative hypo- thesis!, that in order to kill, effector cells have to match up their SD antigens with those of the targets'. On the other hand, cytotoxicity is blocked completely whenever the anti- serum, be it an anti-H-2K or an anti- vaccinia serum, is directed against the target ceHs, and this is taken as evidence for an interaction product being the target. It is important to know whether a similar blocking could be caused by any antiserum directed against the target cells, or only by anti-H-2 or anti-virus serum. Two points are of particular interest in this respect. First, blocking of cytot

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Comparative study of pandemic (H1N1) 2009, swine H...

on Journal of veterinary science December 2012

Comparative study of pandemic (H1N1) 2009, swine H...

on Journal of Veterinary Science Dec 01, 2012

Reply: Effect of the 2009 influenza A/H1N1 pandemi...

on The Pediatric Infectious Disea... January 2013
More articles like this..