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Influence of hyperbaric oxygenation on bilirubin and ditaurobilirubin auto-oxidation and porphyrin-sensitized photo-oxidation

Authors
Journal
Journal of Photochemistry and Photobiology B Biology
1011-1344
Publisher
Elsevier
Publication Date
Volume
5
Identifiers
DOI: 10.1016/1011-1344(90)85045-x
Keywords
  • Hyperbaric Oxygenation
  • Phototherapy Of Jaundice
  • Photodynamic Therapy
  • Photo-Oxidation Of Bilirubin
  • Porphyrin-Sensitized Photo-Oxidation.
Disciplines
  • Medicine

Abstract

Abstract Oxygen concentration controls the reaction rate of porphyrin-sensitized photo-oxidation under constant experimental conditions. The rate of bilirubin and ditaurobilirubin auto-oxidation and meso-tetra-(4-sulphonatophenyl)porphine-sensitized photo-oxidation in aqueous solution increases by about 3.5 times in 0.5 MPa of oxygen. Use of hyperbaric oxygenation in the photodynamic therapy of tumours and in the phototherapy of jaundice is proposed.

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