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Collection of Clonorchis sinensis adult worms from infected humans after praziquantel treatment

Korean Society for Parasitology
Publication Date
  • Adult
  • Aged
  • Aged
  • 80 And Over
  • Animals
  • Antiplatyhelmintic Agents/*Therapeutic Use
  • Clonorchiasis/*Drug Therapy/Epidemiology/*Parasitology
  • Clonorchis Sinensis/Anatomy & Histology/*Isolation & Purification
  • Feces/Parasitology
  • Female
  • Humans
  • Korea/Epidemiology
  • Male
  • Middle Aged
  • Neoplasms/Epidemiology
  • Parasite Egg Count
  • Praziquantel/*Therapeutic Use
  • Risk Factors


A cohort was established for evaluation of cancer risk factors in Sancheong-gun, Gyeongsangnam-do, Korea. As one of the cohort studies, stools of 947 residents (403 males and 544 females, age range: 29-86 years) were screened for Clonorchis sinensis eggs using both Kato-Katz method and formalin-ether sedimentation technique. The overall egg positive rate of C. sinensis was 37.7% and individual EPG (eggs per gram of feces) counts ranged from 24 to 28,800. Eight egg positive residents voluntarily joined a process of collection of the passed worms after praziquantel treatment. A total of 158 worms were recovered from 5 of the 8 treated persons, ranged from 3 to 108 in each individual. The worms were 15-20 mm x 2-3 mm in size, and showed brown-pigmented, red, or white body colors. This is the first collection record of C. sinensis adult worms from humans through anthelmintic treatment and purgation. The adult worms of C. sinensis may be paralyzed by praziquantel and then discharged passively through bile flow in the bile duct and by peristaltic movement of the bowel.

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