Affordable Access

Publisher Website

Resveratrol blunts tumor necrosis factor-α-induced monocyte adhesion and transmigration

Nutrition Research and Practice
The Korean Nutrition Society and The Korean Society of Community Nutrition (KAMJE)
Publication Date
DOI: 10.4162/nrp.2007.1.4.285
  • Original Research
  • Biology
  • Medicine


The leukocyte recruitment and transmigration across the endothelial barrier into the vessel wall are crucial steps in atherosclerosis. Leukocyte trafficking on the endothelium is elicited by induction of endothelial adhesion molecules, and its transmigration is mediated by degradation of basement membrane proteins through enzymatic activity of matrix metalloproteinases (MMP). The current study investigated whether resveratrol, a polyphenol present in grapes and red wine, was capable of inhibiting leukocyte adhesion to tumor necrosis factor (TNF)-α-activated endothelium. It was found that resveratrol inhibited the TNF-α-activated endothelial expression of vascular cell adhesion molecule-1 in a dose-dependent manner. In addition, resveratrol hampered THP-1 monocyte adhesion to activated endothelial cells. This study further examined whether resveratrol interfered with transendothelial migration of leukocytes. The MMP-2 gelatinolytic activity of endothelial cells was enhanced by TNF-α, which was attenuated by an addition of ≥25 µM resveratrol. In addition, 25 µM resveratrol mitigated the MMP-9 activity of THP-1 cells, followed by a marked inhibition of transendothelial migration. These results demonstrated that resveratrol suppressed monocyte adhesion and migration induced by TNF-α through modulating expression of adhesion molecules and gelatinolytic activity of MMP. These findings suggest that dietary resveratrol may be therapeutic agent for inhibiting leukocyte recruitment into the subendothelium during inflammatory atherosclerosis.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

Pine bark extract enzogenol attenuated tumor necro...

on Journal of Agricultural and Fo... Jun 09, 2010

Tumor Necrosis Factor-Induced Neutrophil Adhesion...

on American Journal Of Pathology Jan 01, 2010

Decreased tumor necrosis factor-induced adhesion o...

on American Journal of Clinical N... July 2004

Tumor necrosis factor-induced necrosis: a monocyte...

on Journal of the National Medica... July 1995
More articles like this..