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Downregulation of epithelial MHC II expression in chronic rhinosinusitis with polyps

Authors
Journal
Clinical and Translational Allergy
2045-7022
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
3
Identifiers
DOI: 10.1186/2045-7022-3-s2-o9
Keywords
  • Oral Presentation
Disciplines
  • Biology

Abstract

Downregulation of epithelial MHC II expression in chronic rhinosinusitis with polyps ORAL PRESENTATION Open Access Downregulation of epithelial MHC II expression in chronic rhinosinusitis with polyps Julia Arebro1*, Lotta Tengroth1, Susanna Kumlien Georén1, Ola Winqvist2, Lars-Olaf Cardell1 From 9th Symposium of Experimental Rhinology and Immunology of the Nose (SERIN 2013) Leuven, Belgium. 21-23 March 2013 Background Inflammation in the nasal mucosa has been shown to correlate with the development of CRSwNP (chronic rhinosinusitis with nasal polyps). The mechanism behind this is not fully understood but changes in the activity of the immune system might contribute to the growth of polyps. The present study focuses on the potential role of MHC II (major histocompatibility complex class II). These cell surface proteins are of critical importance for the function of cells in the immune system and poten- tially in nasal polyp development. Methods Biopsies from polyps were obtained from patients with CRSwNP (with and without local steroid treatment dur- ing at least six consecutive weeks) as well as from the mucosa (concha inferior) of healthy control subjects. The obtained specimens were homogenized and subse- quently analysed with flow cytometry. Results Preliminary data indicates a downregulation of MHC II expression in polyp epithelial cells from patients with CRSwNP compared to healthy patients (healthy con- trols: 60,2±7,8; polyps 31,1±7,4; p <0,05). This reduction seems to be independent of the steroid treatment. In contrast, the level MHC II+/CD86+ on epithelial cells was downregulated in patients receiving steroid treat- ment but not in those without treatment. The mechan- isms involved are presently investigated in mice. Conclusion Expression of MHC II and its co-receptor CD86 can be seen on epithelial cells in the mucosa of healthy controls as well as within the polyps of CRSwNP patients. This suggests a role for epithelial cells in the antigen-present- ing procedu

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